Abstract

Lymphoma originates from the lymphatic hematopoietic system and is prone to develop second tumors. We reported a case of lymphoma initially manifesting systematic lymphadenopathies and lung space–occupying lymphoma that developed to lung squamous cell carcinoma in 30 months. The diseases once responded satisfactorily to chemotherapy combined with immunotherapy but progressed after 8 months. Following afatinib administration achieved sustained remission and the progression-free survival is 11 months. Rarely does lymphoma combine with lung cancer and more rarely does lung cancer develop in the original focus of pulmonary lymphoma; first-line and secondary treatment remained potent in treating the complexity.

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