Abstract
Secondary lymphoid organs (SLOs) are sites that facilitate cell-cell interactions required for generating adaptive immune responses. Nonhematopoietic mesenchymal stromal cells have been shown to play a critical role in SLO function, organization, and tissue homeostasis. The stromal microenvironment undergoes profound remodeling to support immune responses. However, chronic inflammatory conditions can promote uncontrolled stromal cell activation and aberrant tissue remodeling including fibrosis, thus leading to tissue damage. Despite recent advancements, the origin and role of mesenchymal stromal cells involved in SLO development and remodeling remain unclear.
Highlights
Secondary lymphoid organs (SLOs) such as spleen and lymph nodes (LNs) play a critical role in host defense
We discuss the different steps involved in the maturation of lymphoid tissue mesenchymal stromal cells and how these cells contribute to tissue remodeling during normal and pathological conditions
Development of SLOs is spatiotemporally regulated during embryogenesis and requires interaction between lymphoid tissue stromal organizer (LTo) cells of mesenchymal origin and lymphoid tissue inducer (LTi) cells derived from the hematopoietic lineage [2,3,4]
Summary
Secondary lymphoid organs (SLOs) such as spleen and lymph nodes (LNs) play a critical role in host defense. This function is ensured by the unique cellular composition of lymphoid tissues characterized by the presence of stationary mesenchymal stromal cells and highly motile hematopoietic cells. Despite recent advances in the field, little is known about the origin and nature of the different mesenchymal stromal cells involved in tissue remodeling during homeostasis and disease. We discuss the different steps involved in the maturation of lymphoid tissue mesenchymal stromal cells and how these cells contribute to tissue remodeling during normal and pathological conditions
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
