Abstract
Introduction. Lymphoepithelioma-like carcinoma (LELC) of the salivary gland is a rare tumor. Currently, surgery with or without radiotherapy is the recommended treatment for all salivary gland carcinomas. However, in contrast to other high-grade salivary gland carcinomas, LELCs are considered radiosensitive. There are only a few published reports of radiotherapy alone for the treatment of salivary gland LELC. Case. We present two cases of LELC of the salivary gland. One was treated with surgery and postoperative radiotherapy, and the other was given a single cycle of chemotherapy and then radiotherapy. Currently, both patients have no evidence of disease. Conclusion. Radiotherapy as a single modality should be reevaluated. The role of systemic chemotherapy to gain systemic control should be addressed due to noteworthy metastatic disease.
Highlights
Lymphoepithelioma-like carcinoma (LELC) of the salivary gland is a rare tumor
Significant correlation has been reported between this tumor type and the Epstein Barr virus (EBV) [2,3,4,5] and, more recently, with the human papilloma virus (HPV) [3] as well
Carcinomas with similar morphologic features have rarely been described in other organs and are referred to as lymphoepithelioma-like carcinoma (LELC)
Summary
Lymphoepithelioma is a term that was used by Regaud and Schmincke in 1921 to describe certain tumors of the nasopharynx [1]. Carcinomas with similar morphologic features have rarely been described in other organs and are referred to as lymphoepithelioma-like carcinoma (LELC) These have primarily been observed in the upper aerodigestive tract, including the salivary glands (mainly parotid), oral cavity, and tonsils, but have been found in the stomach, thyroid, bladder, ureters, uterine cervix, ovaries, skin, and other anatomic locations [4,5,6,7,8,9]. These tumors comprise a significant proportion of salivary gland carcinomas seen in Chinese and Eskimo populations [5, 10]. In this paper we review two cases of LELC of the salivary gland that were treated with different treatment modalities and discuss related literature
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