Abstract
Lymphoepithelial carcinoma is an undifferentiated neoplasm arising in the nasopharyngeal mucosa.The incidence of Lymphoepithelial carcinoma in the Indian subcontinent is not well documented.The aim of the present study compares the incidence, age,sex distribution ,clinical presentation ,and relationship of EBV virus and LEC in sporadic cases of LEC from India world statistics. And also the role of LatentMembraneProtein-1in diagnosing the EBV association.Malignant lesions with prominent lymphoepithelial component were taken for the study .Pancytokeratin,lymphoma markers were used to confirm the histopathological diagnosis.LMP-1 was used to demonstrate EBV in tissue sections.It was observed that nasopharynx being the commonest site for LEC.It showed male preponderance with bimodal age distribution.Intense staining of LMP-1was demonstated in LEC of nasopharynx than other sites. Hence confirming the strong EBV association in LEC of nasopharynx. It was also observed that LEC with early lymphnode metastasis showed intense LMP-1 staining.Thus confirming the progressiveness and metastatic potential of LMP-1 expression in EBV associated LEC when compare to EBV negative LEC. Hence LMP-1 proves to be a useful IHC marker in establishing the metastatic potential of LEC and the need for early diagnosis and treatment of LEC.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
