Abstract
In normal human peripheral blood, there is a population of large lymphocytes with slightly eccentric nuclei and abundant pale-blue cytoplasm containing many azurophilic granules. These lymphocytes have been termed<i>large granular lymphocytes</i>(LGLs). It is now clear that almost all natural-killer and antibody-dependent cell-mediated cytotoxic activity resides in this population of cells.<sup>1,2</sup>Despite their morphologic similarity, immunologic analysis has shown striking heterogeneity in their surface antigens.<sup>3,4</sup>Almost all of these cells bear surface receptors for the Fc fragment of IgG, but some express antigens generally found on T-lymphocytes. Others show surface antigens carried by myelomonocytic cells. This may indicate the presence of multiple distinct subpopulations of cells or a single population of cells expressing different surface antigens at different stages of maturation or functional activity.<sup>5</sup>Whether LGLs are derived from the T cell or the myelomonocytic lineage is still not clear. There have been an increasing number
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