Abstract
Lymphocytopenia is a common accompaniment of renal failure. To study this phenomenon, guinea pigs were made uremic by ureteral ligation. In one day, peripheral lymphocytes had decreased by 44%. The phenomenon is not species-specific since both rats and rabbits exhibited early peripheral blood lymphocytopenia after bilateral nephrectomy or ureteral ligation. Lymphocytopenia due to the markedly elevated blood cortisol levels following ureteral ligation is unlikely for two reasons. Normal guinea pigs injected with large amounts of corticosteroids showed no lymphocytopenia. Adrenalectomized rats underwent bilateral nephrectomy with resultant increase in plasma creatinine and marked fall in peripheral lymphocytes. The rapid development of the lymphocytopenia associated with uremia would favor increased destruction rather than decreased production.
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