Abstract
Lymphocytopenia as an independent predictor of early recurrence in breast cancer.
Highlights
The role of immunological mechanisms in controlling the growth of malignant tumours is controversial (Underwood, 1974) and, in the case of the common human malignancies, the evidence is slight
For the 216 cases with complete data, the proportional hazards model (Cox, 1972) was used to examine the effects of multiple factors on time to relapse; validity of the proportionality assumption was confirmed by inspection of log minus log plots and goodness of fit assessed by plotting the cumulative hazard function of residuals
There was no difference in pre-operative peripheral lymphocyte counts (PLC) between those women found to have nodal involvement and those with tumour-free nodes
Summary
The role of immunological mechanisms in controlling the growth of malignant tumours is controversial (Underwood, 1974) and, in the case of the common human malignancies, the evidence is slight. Survival analysis was performed by the productlimit method using Breslow's generalisation of the Wilcoxon test for group contrasts (Breslow, 1970). There was no difference in pre-operative peripheral lymphocyte counts (PLC) between those women found to have nodal involvement and those with tumour-free nodes (mean +s.d. 2.13+1.04 and 2.28+1.35x 10l9-', P>0.3).
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