Lymphocytic Hypophysitis With Subsequent Development of Graves Disease

Abstract

Lymphocytic hypophysitis (LH), a rare pituitary condi- tion mimicking pituitary macroadenoma, presents most commonly in the peripartum period. This presumably autoimmune disease can occur as an isolated entity or be associated with other autoimmune conditions. The association of LH with Graves disease is extremely rare. We present the clinical course and laboratory evaluation of a woman who developed LH in the third trimester of her fifth preg- nancy. The patient then developed overt Graves disease 2 years later. A 21-year-old black woman with an unremarkable medical and obstetric history developed severe headache and partial visual loss during the third trimester of her fifth pregnancy. Evaluation revealed a large partially hemorrhagic pituitary mass with suprasellar exten- sion compressing the optic chiasm. Pathologic evaluation after transsphenoidal surgery confirmed the resected mass to be lympho- cytic hypophysitis. Postoperative evaluation documented persistent panhypopituitarism and central diabetes insipidus. She remained clinically stable for 2 years receiving physiological doses of glu- cocorticoid, levothyroxine, and desmopressin. She then developed symptoms and signs of hyperthyroidism. Levothyroxine was discon- tinued and additional evaluation was consistent with Graves disease. Patients with severe headache and visual difficulties during preg- nancy or the postpartum period should have a detailed neurologic and endocrinologic evaluation. Lymphocytic hypophysitis, a rare pituitary condition, should be considered in the differential diagno-