Lymphocytic Hypophysitis in a Pregnant Woman: A Case Report

Abstract

Introduction: Lymphocytic hypophysitis was first reported in 1962, it is a rare immune-mediated inflammatory disorder that causes pituitary dysfunction. Case report: We report the case of 29-year-old woman at 37 weeks gestation, diagnosed with lymphocytic hypophysitis. The patient received appropriate hormonal replacement treatments. The evolution was favorable. Conclusions: Lymphocytic hypophysitis is a rare auto-immune disease, occurring mainly in women during the peripartum phase. Clinical presentation is variable, it should be considered in female pregnant patients or in the early postpartum period, with pituitary hypertrophy and/or hormonal deficiencies with diabetes insipidus. To date, the management of this disease is challenging. Prospective controlled studies are necessary but difficult to conduct due to the rarity of lymphocytic hypophysitis.