Abstract
Marchi et al 1 Marchi AG Marchi MAM Mastella G et al. Abnormal β-glucuronidase activity in cystic fibrosis. Helv Paediatr Acta. 1973; 28: 427-435 PubMed Google Scholar were the first to report that lymphocytes were hyporesponsive to phytohemagglutinin (PHA) when cultured in the presence of serum from patients with cystic fibrosis (CF). Normally, β-glucuronidase activity increases in lymphocytes that are stimulated to transform by PHA, but when serum from CF homozygotes or heterozygotes is present in the culture media, the increase in β-glucuronidase activity is significantly reduced.
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