Abstract
BackgroundNo previous study examined whether statins affect lymphocyte cytokine release in patients with isolated hypertriglyceridemia. MethodsThe study included 46 patients with elevated triglyceride levels and peripheral artery stenosis, randomly assigned to receive simvastatin or placebo. Plasma lipids, glucose homeostasis markers, plasma C-reactive protein and lymphocyte cytokine release were measured at baseline and at the end of the treatment. ResultsNinety-day simvastatin treatment reduced lymphocyte release of TNF-α, interleukin-2 and interferon-γ, which was accompanied by a decrease in plasma C-reactive protein. ConclusionThe obtained results suggest that statins produce lymphocyte-suppressing and systemic anti-inflammatory effects in patients with isolated hypertriglyceridemia.
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