Abstract
Peripheral blood lymphocytes from 25 normal persons and 47 patients with immunodeficiency diseases were studied for the presence of human thymus-lymphoid tissue antigen (HTLA) and their responsiveness to PHA. Whereas in normal persons, HTLA values were consistently around 36%, 17 immunodeficient patients had low numbers of HTLA-positive lymphocytes in their peripheral blood. In general, HTLA values corresponded with PHA responsiveness ( 36 47 ), however, a number of discordant situations were observed. These results suggest that HTLA may be a useful marker in evaluating an immunologically relevant lymphocyte population in clinical situations. This population is most likely of thymus origin (4,5) and appears to be associated with PHA responsiveness in most situations. On the other hand, the dissociation of these markers in 11 patients suggests that they detect either distinct but overlapping populations, different phases of differentiation of a single lymphocyte population or that the cells involved may be perturbed independently by exogenous factors, such as infections.
Published Version
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