Abstract
Objective: Cellular immune response, specifically tumor-infiltrating lymphocytes (TILs), correlates with survival in ovarian carcinoma; however, specific gene expression patterns for this response remain poorly understood. Our objective was to evaluate the impact of a subset of immune-related gene expression on prognosis ovarian high-grade serous carcinoma (OHGSC), with a focus on lymphocyte specific kinase (LCK). Prognostic value of LCK status was compared to the previously validated metric of cytolytic activity score (CYT).
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