Abstract
Lymphocyte responsiveness in vitro and serum levels of specific IgE antibody to mite extracts ( Dermatophagoides farinae) were evaluated in mite-sensitive asthmatic patients and in nonatopic individuals. Lymphocytes from untreated mite-sensitive patients (n = 16) responded to mite extracts with greater 3H-thymidine uptake than those from nonatopic individuals (n = 20; p < 0.01). Specific IgE antibody and total IgE levels were significantly higher in mite-sensitive patients than those in nonatopic individuals. These results suggest that mite-sensitive patients respond to mite allergen with exaggerated lymphocyte proliferation as well as with enhanced specific IgE antibody production. Lymphocyte response to mite extracts was significantly lower in the patients with long-term dust immunotherapy than that in the untreated patients (p < 0.05), but there was no significant difference in the total IgE and the specific IgE antibody levels between them. Lymphocyte response to Candida albicans was not significantly affected in these patients. These results suggest that as far as mite allergy is concerned, there is some difference in the effect of immunotherapy between lymphocyte proliferative response and specific IgE antibody to mite allergen.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
