Abstract
Ten patients with juvenile rheumatoid arthritis and age‐ and sex‐matched healthy controls were investigated in pairs. The patients were found to have both normal proportions and normal absolute numbers of T lymphocytes, B lymphocytes, and the Fc‐receptor‐bearing lymphoid cells in peripheral blood. No abnormality of mitogen‐induced lymphocyte transformation was observed. Lymphocyte‐mediated cytotoxicity induced by phytohemagglutinin (PHA) or anti‐target cell antibodies was also found to be normal. As in an earlier study, impaired delayed hyper‐sensitivity by skin testing was observed in the patient group, thus indicating a dissociation between in vivo and in vitro parameters of lymphoid cell function.
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