Abstract

Rapidly progressive glomerulonephritis (RPGN) may progress to end-stage renal failure within weeks and to death from organ damage induced by systemic vasculitis or from immune system failure due to immunosuppressive therapy. Death or the need for dialysis has variously been reported to occur in 17% to 73% of patients treated for RPGN. 1 Bolton WK The role of high dose steroids in nephritic syndromes: the case of aggressive use. in: Narins RG Controversies in nephrology and hypertension. Churchill Livingstone, New York1984: 421-459 Google Scholar , 2 Frasca GM Zoumparidis NG Borgnino LC et al. Plasma exchange treatment in rapidly progressive glomerulonephritis associated with anti-neutrophil cytoplasmic autoantibodies. Hemapheresis. 1992; 15: 181-184 Google Scholar The need exists for a means promptly to stop disease activity without compromising the patient's immune system.

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