Lympho-vascular space invasion indicates advanced disease for uterine papillary serous tumors arising from polyps.

Selcuk Ilker,Gungor Tayfun,Korkmaz Elmas,Salim Erkaya,Turker Mengu,Ozgu Emre

doi:10.7314/apjcp.2015.16.10.4257

Abstract

Uterine papillary serous tumors are rarely seen and behave aggressively. Our aim was to evaluate uterine papillary serous tumors arising from polyps. Clinicopathological data of patients with uterine serous cancer arising from a polyp at the Gynecological Oncology Department of Zekai Tahir Burak Women's Health Education and Research Hospital were reviewed retrospectively. We analyzed patients according to FIGO 2009 staging system as stage 1A and higher than stage 1A (3 and 6, respectively). All the patients were postmenopausal. Mean CA-125, CA-19.9 and CA15.3 levels were elevated in higher than stage 1A group. However we did not find a statistical difference between age, parity, polyp size, CA-125, CA-15.3, CA-19.9 and CEA levels. Lympho-vascular space invasion (LVSI) showed predictivity for advanced disease (p=0.025). The histopathologic nature of uterine serous carcinoma is a unique entity. LVSI is a prognosticator for defining an advanced stage uterine papillary tumor.

Highlights

Endometrial cancer is the most common gynecologic malignancy (Siegel et al, 2013)
Uterine papillary serous carcinoma (UPSC) is rarely seen; less than 10% of all uterine cancers (Moore and Fader, 2011), it behaves very aggressively and uterine papillary serous carcinoma (UPSC) represents more than 50% of all endometrium cancer related deaths and recurrences
A total of 9 uterine serous carcinoma patients where the tumor arise from a polyp were reviewed

Summary

Introduction

Endometrial cancer is the most common gynecologic malignancy (Siegel et al, 2013). Endometrioid histology is the most commonly detected type with a favorable prognosis. Approximately 60% of UPSC patients are diagnosed with greater than stage 1 disease (Slomovitz et al, 2003). Lymphatic drainage is an important way of tumor dissemination for endometrial cancers (Oz et al, 2014) and histology of UPSC is an independent predictor of postoperative adjuvant treatment in early stage endometrial cancer (Demiral et al, 2014). Uterine papillary serous tumors are rarely seen and behave aggressively. Our aim was to evaluate uterine papillary serous tumors arising from polyps. Materials and Methods: Clinicopathological data of patients with uterine serous cancer arising from a polyp at the Gynecological Oncology Department of Zekai Tahir Burak Women’s Health Education and Research Hospital were reviewed retrospectively. LVSI is a prognosticator for defining an advanced stage uterine papillary tumor

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