Lymphatic senescence and possible clinical implications

Abstract

Lower limb edema is a frequent occurrence in the geriatric age. Among the possible causes, the deterioration of lymphatic function caused by its senescence is usually overlooked. There is multiple evidence of aging of the lymphatic system, based on in vivo observations, both in humans and in animal models, and on cadavers. The alterations concern both the morphological and ultrastructural level, as well as functionality. On the basis of the available data, some clinical pictures can be better understood and new areas of investigation envisaged.