Abstract
Background: Controversy has been reported concerning the extent of lymphadenectomy during esophageal adenocarcinoma (EAC) resection surgery in the era of multimodal therapy. Due to unfavorable biology, there is potential for the neoplasia to persist after neoadjuvant therapy. Extended lymphadenectomy might bring a survival advantage to these patients. This systematic review and meta-analysis evaluates whether the extension of lymphadenectomy has impact on overall survival (OS) in patients with EAC submitted to esophagectomy preceded by neoadjuvant therapy.
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