Abstract
Lycopene is the most abundant carotenoid in tomatoes, which has been identified to have the properties of anti-inflammation in addition to the capability to inhibit the expression of adhesion molecules. Intercellular adhesion molecules play a critical role in the pathogenesis of psoriasis. Here, we report that the topical use of a lycopene decreased imiquimod (IMQ)-induced psoriasis-like inflammatory responses, the progress of which was based on adhesion molecules. In vitro analysis showed that lycopene decreased keratinocyte and monocyte adhesion. Evidence suggests that intercellular adhesion molecule-1 (ICAM-1) is a main mediator of psoriasis pathogenesis. Therefore, it will be interesting to investigate the factors that contribute to the lycopene-mediated inhibition of ICAM-1 expression in psoriasis. We expect that lycopene will with potential value in the treatment of psoriasis.
Highlights
Psoriasis is a chronic inflammatory skin disease that is characterized by the formation of scaly, erythematous plaques
There has been more evidence that indicates that the interleukin-23 (IL-23) and IL-17A signaling pathway plays a main role in the development of psoriasis [5]
The results show that imiquimod (IMQ)-induced psoriasis lesions in mice are similar to human psoriasis lesions with regard to their histological and phenotypic characteristics and their development
Summary
Psoriasis is a chronic inflammatory skin disease that is characterized by the formation of scaly, erythematous plaques. Tasato et al found that intercellular IL-23p19 increased the expression of adhesion molecules on the surface of endothelial cells [6]. None of these agents are absolutely effective and safe for the treatment of this disease. Lycopene inhibits NF-κB activation and adhesion molecule expression in endothelial cells [11]. Lycopene plays a multifunctional role as a nonsurgical support in the treatment of oral diseases, including leukoplakia and oral submucous fibrosis [12]. According to previous studies HaCat cells widely used as a model of psoriatic dermatitis. This study investigated the effects of lycopene gel and lycopene by oral gavage in an IMQ-induced psoriasis-like mouse model. We anticipated obtaining evidence that supports a role for lycopene in treatment of psoriasis
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