Abstract
We investigated the effects of lycopene on hepatic oxidant-antioxidant status during N-methyl-N′-nitro-N-nitrosoguanidine and saturated sodium chloride (S-NaCl)-induced gastric carcinogenesis. The extent of lipid peroxidation and the levels of reduced glutathione (GSH) and activities of the GSH-dependent enzymes glutathione peroxidase (GPx), glutathione S-transferase (GST) and glutathione reductase (GR) were used to monitor the peroxidative balance. Enhanced lipid peroxidation in the livers of tumor-bearing animals was accompanied by significant decreases in the activities of GSH, GPx, GST and GR. Administration of lycopene significantly lowered the levels of lipid peroxides and enhanced GSH levels and activities of GSH-dependent enzymes. Our results suggest that lycopene blocks experimental gastric carcinogenesis by upregulating GSH-dependent hepatic detoxification systems thereby protecting against carcinogen-induced oxidative damage.
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