Abstract
Gentamicin is an aminoglycoside antibiotic used against gram-negative bacterial infections. In the face of antibiotics, gentamicin also has a toxic effect on kidney. This study investigated the protective role of lycopene against gentamicin induced nephrotoxicity. Results of this works found that lycopene has a great protective effect on the oxidative status of the kidney challenged with gentamicin and significantly ameliorated (P £ 0.05) the level of oxidative markers MDA, GPx and SOD in kidney cells. Kidney function markers (serum urea and creatinine) were ameliorated by using lycopene in comparison with mice challenged by gentamicin. Results of this work showed that lycopene decreased the pro-inflammatory cytokines (IL-6 and TNF-á) and anti-inflammatory cytokines (IL-4 and IL-10). mRNA expression rate of different investigated cytokine markers were modified significantly (P £ 0.05) in lycopene treated group. Serum glucose also adjusted significantly using lycopene. Oxidative stress results were confirmed by histopathological investigations those showed a protective effect of lycopene of kidney tubules.
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