Abstract
I HAVE developed an assay for the measurement of luteotrophin in hypophysectomized adult mice which depends on the increase in the weight of a damaged horn of the uterus (formation of deciduomata). Mice were hypophysectomized on the first day of diœstrus and 48 h later the endometrium of the right horn of the uterus was injured. The animals were injected daily for 5 days with a preparation of luteotrophin commencing immediately after hypophysectomy and killed on the sixth day. The response was recorded as positive if the weight of the damaged horn was at least 11 mg greater than the weight of the control horn. The results were expressed as the percentage of animals with a positive response and a probit transformation was used for parallel line assays. Details of this method will be published shortly.
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