Abstract
1. The luteoma of pregnancy is a benign tumor of lutein-like cells occurring most often in patients of high parity and usually discovered at laparotomy at or near term.2. Twelve examples of this lesion are presented of which 6 were multinodular and 4 of these were bilateral.3. The pregnancy luteoma has characteristic microscopic features including acidophilic granular cytoplasm with sparse lipid, and a distinctive pattern of reticulum fibers.4. The tumors most likely are derived from theca-lutein cells of atretic follicles stimulated by chorionic gonadotropin, although some may be derived from stroma-lutein cells. In one instance, the pregnancy luteoma originated in the theca interna of a corpus luteum of pregnancy.5. There is evidence that the lesion spontaneously regresses following the drop in chorionic gonadotropin after delivery.
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