Abstract
Luteolin, 3', 4', 5,7-tetrahydroxyflavone, belongs to a group of naturally occurring compounds called flavonoids that are found widely in the plant kingdom. It possesses many beneficial properties including antioxidant, anti- inflammatory, anti-bacterial, anti-diabetic and anti-proliferative actions. Colorectal cancer (CRC) is a leading cause of cancer related deaths worldwide. Many signaling pathways are deregulated during the progression of colon cancer. In this review we aimed to analyze the protection offered by luteolin on colon cancer. During colon cancer genesis, luteolin known to reduce oxidative stress thereby protects the cell to undergo damage in vivo. Wnt/β-catenin signaling, deregulated during neoplastic development, is modified by luteolin. Hence, luteolin can be considered as a potential drug to treat CRC.
Highlights
Flavonoids are biologically active polyphenolic compounds widely distributed in plants
In this review we aimed to analyze the protection offered by luteolin on colon cancer
Published reports showed that luteolin reduces tumor number, inhibits the lipid peroxidation and restores the antioxidant enzymes during 1, 2-Dimethyl hydroxide-induced colon cancer in rats (Manju et al, 2005; Manju and Nalini, 2005; Manju and Nalini, 2007)
Summary
Flavonoids are biologically active polyphenolic compounds widely distributed in plants. Belonging to the flavone group of flavonoids, luteolin has a C6-C3-C6 structure and possesses two benzene rings (A, B), a third, oxygencontaining (C) ring, and a 2-3 carbon double bond. The hydroxyl moieties and 2-3 double bonds are important structure features in luteolin that are associated with its biochemical and biological activities (Chan et al, 2003). Lipid peroxidation (LPO) is a free radical mediated process It is involved in the formation of lipid radicals, a rearrangement of the unsaturated lipids that consequences in a variety of degraded products like alkanes, malondialdehyde (MDA), conjugated dienes and lipid hydroperoxides and eventually damage to cells (Upsani et al, 2001). Published reports showed that luteolin reduces tumor number, inhibits the lipid peroxidation and restores the antioxidant enzymes during 1, 2-Dimethyl hydroxide-induced colon cancer in rats (Manju et al, 2005; Manju and Nalini, 2005; Manju and Nalini, 2007). In Balb/C mouse tosis by modulating Bcl[2], Bax and Caspase-3
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
