Abstract
The quantitative relationship between LHRH and LH secretion was investigated in the rhesus monkey. Pituitary stalk blood was collected using a trans-sphenoidal surgical approach and analyzed for LHRH by radioimmunoassay. Stalk blood was collected from 3 groups of monkeys: a) 5 animals in the mid-follicular phase of the menstrual cycle exhibiting low peripheral plasma LH levels, b) 7 animals undergoing preovulatory-like LH surges one of which occurred spontaneously and 6 of which were induced by estradiol benzoate treatment, and c) 4 ovariectomized animals exhibiting tonically elevated LH levels. LHRH was detected in the stalk plasma of all animals (> 10 pg/ml) but none was found in peripheral plasma. The correlation coefficient for peripheral plasma LH levels and stalk plasma LHRH levels was 0.66 (P < 0.01) when all animals were considered and 0.79 (P < 0.01) when only the follicular phase and preovulatory animals were considered. Moreover, LHRH levels in stalk plasma were significantly elevated (P <0.05)...
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