Abstract
LH-RH was administered to anovulatory patients with hypogonadotropic hypogonadism to convert them to clomiphene responders. This synthetic decapeptide was injected intramuscularly in doses of 100 μg twice a week for six weeks. Diagnostic tests of progestin, LH-RH and gonadotropin were performed before and after LH-RH treatment. Seven out of nine patients became clomiphene or clomiphene-hCG responders after one course of treatment. One patient became a clomiphene-hCG responder after one additional course of treatment. One patient with hypothyroidism did not respond to clomiphene citrate with two courses of treatment. The results of the progestin test and gonadotropin test and the basal E2 levels after this treatment were correlated with the ovulatory response to clomiphene therapy or to clomiphene-hCG therapy after LH-RH treatment. But basal gonadotropin levels and the mode of gonadotropin responses of the LH-RH test were not necessarily correlated with the ovulatory response to clomiphene or clomiphene-hCG therapy after LH-RH treatment.
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