Abstract
Six analogs of LH-RH lacking N-terminal pGlu ring structure, Gly 1-LH-RH, formyl Gly 1-LH-RH, acetyl Gly 1-LH-RH, propionyl Gly 1-LH-RH, palmitoyl Gly 1-LH-RH and acetyl Ala 1-LH-RH were synthesized. The Gly 1 analog was inactive, whereas acyl Gly 1 analogs except palmitoyl Gly 1 analog showed small but significant LH-RH activity in spite of the lack of the pyrrolidone ring structure. These findings suggest that the -CO-NHCHCO- group is the minimum necessary part of the pGlu residue to exhibit the biological activity.
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