Abstract
Effects of passive immunization against gonadotrophin-releasing hormone (GnRH) on luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion were examined in six ovariectomized (OVX) ewes during the breeding season (8L:16D). The same amount of rabbit anti-GnRH serum was administered by intravenous infusion or median eminence (ME) perfusion over 30 h. Administration of anti-GnRH serum by both routes failed to affect FSH ( P>0.05) but equally reduced basal and mean circulating LH concentrations and LH pulse amplitude ( P<0.05). Luteinizing hormone pulse amplitude was also reduced by ME perfusion with vehicle ( P<0.05). Luteinizing hormone interpulse interval was not affected by intravenous infusion with anti-GnRH serum but was increased by ME perfusion with anti-GnRH serum ( P<0.05). The results suggested that targeting the ME of the ovariectomized ewe with perfusion of GnRH antiserum for 30 h blocked pulsatile LH secretion, leaving only basal secretion, and had no effect on FSH secretion.
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