Abstract
Patients with psychiatric disorders, including schizophrenia and bipolar disorder, are reported to suffer from sleep disorders. To investigate the effects of lurasidone on sleep architecture in rats using sleep electroencephalography. Seven adult male rats were used in this study. A pair of electrode wires was implanted in the dura of each rat and electromyograms were recorded from their dorsal neck muscles. Drugs were administered at the start of the lights-on period, and electroencephalograms (EEG)were recorded for 6 hours in individual soundproof boxes. The course of sleep in rats has been classified into 3 stages: WAKE, non-REM (NREM) sleep and rapid eye movement (REM) sleep. Total NREM duration, REM duration, and latencies to the initial REM and NREM were calculated. In addition, the number and mean duration of bouts in every 2-hour period were calculated in each stage. EEG power in each of the following frequency bands during NREM sleep was quantified: delta (0.5-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (12-30 Hz) and gamma (30-80 Hz). Lurasidone shortened REM sleep duration and prolonged the mean duration of one bout in WAKE and NREM sleep. Quantitative frequency analyses during NREM sleep revealed that lurasidone increases slow waves and decreases fast waves. The serotonin 5-HT 1A receptor partial agonist, tandospirone, and selective serotonin 5-HT 7 receptor antagonist, SB-258741, also exhibited REM-inhibitory effects similar to those of lurasidone. These results suggest that lurasidone ameliorates sleep disorders associated with psychosis through, at least partly, serotonin 5-HT 1A and serotonin 5-HT 7 receptors.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.