Lupus Nephritis In Systemic Lupus Erythematosus

Nazarova Nigina Otabek Qizi,Madazimova Dilrux Xayotjonovna,Abduhalikova Nigora Fahriddinovna,Jabbarov Azim Atakhanovich

doi:10.37547/tajmspr/volume02issue10-22

Nazarova Nigina Otabek Qizi, Madazimova Dilrux Xayotjonovna + Show 2 more

Open Access

https://doi.org/10.37547/tajmspr/volume02issue10-22

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Abstract

The pathogenesis, clinic, and treatment of kidney damage in patients with systemic lupus erythematosus (SLE) are considered. It is noted that if at the beginning of the disease signs of kidney damage are present in 25-50% of SLE patients, then later they are detected in almost 60% of adults and 80% of children. Variants of kidney damage in SLE are described. The pathogenesis of SLE is generally considered on the model of lupus nephritis. The morphological classification of lupus nephritis, features of the main nephrological syndromes, and clinical variants (active and inactive) are presented. It is indicated that the treatment strategy depends on the activity of the disease, the clinical and morphological variant of lupus nephritis.

Highlights

Кidney damage in systemic lupus erythematosus (SLE) remains one of the most common, severe and prognostically important.The possibilities of modernThe USA Journals Volume 02 Issue 10-2020 immunosuppressive therapy, on the one hand, have reduced the proportion of patients with end-stage renal failure, and on the other hand, they have demonstrated the prognostic importance of kidney damage for the course of the disease as a whole [1,2,3,4,5]
SLE is characterized by multifaceted kidney damage, and by the transformation of one variant into another during the course of the disease. This applies both to the morphological classes of lupus nephritis itself, and to the combination or independent development of nephropathy caused by vascular lesions [6,7,8]
Lupus nephritis is a paradigm of immunocomplex inflammation, the mechanism of development of which reflects the pathogenesis of SLE in General

Summary

INTRODUCTION

Кidney damage in systemic lupus erythematosus (SLE) remains one of the most common, severe and prognostically important. The USA Journals Volume 02 Issue 10-2020 immunosuppressive therapy, on the one hand, have reduced the proportion of patients with end-stage renal failure, and on the other hand, they have demonstrated the prognostic. Importance of kidney damage for the course of the disease as a whole [1,2,3,4,5]. 25-50% of patients with SLE have signs of kidney damage at the beginning of the disease, and later they are diagnosed in almost 60% of adults and 80% of children [1, 5]. Kidney damage in SLE is currently multi-faceted (table 1)

THE MAIN RESULTS AND FINDINGS

INACTIVE NEPHRITIS with minimal urinary syndrome or subclinical proteinuria

CONCLUSION