Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organs. The diverse manifestations can be confusing and may obscure the diagnosis, especially when few clues are present at the beginning. Serositis is 1 of the various presentations, and the presence of LE (lupus erythematosus) cells in the body fluid may be a hint leading to the final diagnosis of SLE. Herein, we present 2 male patients diagnosed with SLE with an initial presentation of pleuritis. Although SLE is unusual in this population, the finding of LE cells in the pleural effusion prompted an immunologic survey. The diagnosis of SLE was confirmed with the high titer of ANA and antids ANA. The literature regarding LE cells is reviewed, and we conclude that cytologic examination of the body fluid is not only a useful tool for detecting malignant cells, but also has a role in detecting benign diseases, such as SLE.
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