Abstract
The presence of immunoglobulin deposits at the dermal-epidermal junction (DE J) in skin lesions of patients with lupus erythematosus (LE) was first noted by Burnham and co-workers 1 in 1963. Independently, Cormane 2 in 1964, noted the same findings but also reported that similar immunoglobulin deposition occurs in normal-appearing skin of patients with systemic LE (SLE). Tan and Kunkel, 3 Ten Have-Opbroek, 4 and Pohle and Tuffanelli 5 soon confirmed these findings and suggested that the presence of immunoglobulin deposits in normal-appearing skin provided a means of differentiating chronic discoid LE (DLE) and SLE. Although not positive in all cases of SLE, the “lupus band” test or LE band test (immunoglobulin deposits in clinically normal skin) is one of several useful tests for confirming the diagnosis of SLE.
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