Lupine allergy cross-reactivity with Fabaceae family

Abstract

Lupine seed IgE-mediated food allergy is an underdiagnosed hidden allergen. Lupine seed, also known as the Lupinus species, is cross-reactive with other members of the legume Fabaceae family: peanut, pea, chickpea, lentil, soybean, and beans. Lupine seed allergy is a known cause of occupational allergy, oral allergy syndrome, and anaphylaxis with a low eliciting dose. As the prevalence of lupine seed increases in Western diets, particularly through wheat alternative flours and pastries, identification of this allergy in patients with other legume allergies is increasingly important.