Abstract

Lung ultrasound (LUS) and chest computed tomography (chest CT) are largely employed to evaluate coronavirus disease 2019 (COVID-19) pneumonia. We investigated semi-quantitative LUS and CT scoring in hospitalized COVID-19 patients. LUS and chest CT were performed within 24 h upon admission. Both were analyzed according to semi-quantitative scoring systems. Subgroups were identified according to median LUS score. Patients within higher LUS score group were older (79 vs 60 years, p<0.001), had higher C-reactive protein (CRP) (7.2 mg/dl vs 1.3 mg/dl, p<0.001) and chest CT score (10 vs 4, p=0.027) as well as lower PaO2/FiO2 (286 vs 356, p=0.029) as compared to patients within lower scores. We found a significant correlation between scores (r=0.390, p=0.023). Both LUS and CT scores correlated directly with patients age (r=0.586, p<0.001 and r=0.399, p=0.021 respectively) and CRP (r=0.472, p=0.002 and r=0.518, p=0.002 respectively), inversely with PaO2/FiO2 (r=−0.485, p=0.003 and r=−0.440, p=0.017 respectively). LUS score only showed significant correlation with hs-troponin T, NT-pro-BNP, and creatinine (r=0.433, p=0.019; r=0.411, p=0.027, and r=0.497, p=0.001, respectively). Semi-quantitative bedside LUS is related to the severity of COVID-19 pneumonia similarly to chest CT. Correlation of LUS score with markers of cardiac and renal injury suggests that LUS might contribute to a more comprehensive evaluation of this heterogeneous population.

Highlights

  • In the late 2019, the outbreak in China of a novel type of betacoronavirus 2019-nCov, later renamed severe acuteGrazia Portale and Federica Ciolina contributed to the manuscript and should be considered as co-first author This article is part of the Topical Collection on COVID-19SN Compr

  • We reported Lung ultrasound (LUS) and CT findings in a cohort of patients affected by COVID-19

  • COVID-19 is featured by quite heterogeneous clinical behavior, ranging from asymptomatic cases to different degrees of flu-like symptomatology and bilateral pneumonia complicated by respiratory failure [5, 11]

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Summary

Objectives

The aim of the present study was to investigate semi-quantitative assessment of LUS and CT findings in a cohort of patients hospitalized for COVID-19 pneumonia, providing comparison with clinical and laboratory data

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