Lung Transplantation from A Donor with Previous SARS-CoV-2 Infection: 1-Year Outcomes

Abstract

Few reports have described successful lung transplantation from a donor with a history of SARS-CoV-2 infection, and outcomes beyond 3 to 6 months remain unknown. After weighing the urgency and life-saving benefits of lung transplantation against the risk of viral transmission, we successfully performed a bilateral lung transplant from a donor with confirmed SARS-CoV-2 infection with mild symptoms 2 months before donation. At 1 year after transplant, there is no evidence of donor-derived viral transmission, and allograft function is excellent and stable, with FVC of 3.66 L (77% predicted) and FEV<sub>1</sub> of 3.08 L (85% predicted). With careful selection, lung transplantation from a donor with a history of mild SARS-CoV-2 infection was performed safely, with good allograft survival.