Abstract
The pulmonary humoral immune response and pathologic changes caused by a combined aerogenic exposure of mice to an airborne contaminant (sulfuric acid, H 2SO 4) or an adjuvant ( Bordetella pertussis) in conjunction with a particulate antigen (sheep red blood cells, SRBC) were studied. Daily inhalation of H 2SO 4 with consequent weekly intranasal instillation of SRBC induced severe pulmonary injury. Serum and bronchial wash hemagglutinating antibody titers reached higher levels in mice that were exposed to H 2SO 4 aerosol. An adjuvant ( B. pertussis) in conjunction with SRBC, instilled intranasally and followed by weekly SRBC intranasal immunization, produced pulmonary inflammation without exposure to H 2SO 4. This animal model allows study of the role of environmental factors acting synergistically with inhaled antigens in induction of various types of immune lung injury.
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