Lung inhomogeneities, inflation and [18F]FDG uptake rate in ards

Massimo Cressoni ,K Nikolla,A Cammaroto,Miriam Gotti ,Eleonora Carlesso ,Andrea Colombo ,Dario Massari ,Ilaria Algieri ,Paolo Cadringher ,Matteo Brioni ,Davide Chiumello ,Luciano Gattinoni

doi:10.1186/2197-425x-3-s1-a90

Abstract

In ARDS lung parenchyma presents great variability in inflation, lung inhomogeneities and [18F]FDG uptake. In fact, inflation progressively decreases along the sternum-vertebral axis[1] leading to further inhomogeneities that may act as “stress raiser”.[2] That can activate a local inflammatory response leading to edema.

Highlights

In ARDS lung parenchyma presents great variability in inflation, lung inhomogeneities and [18F]FDG uptake
We aimed to examine the voxel by voxel relationship between [18F]FDG uptake and inhomogeneity according to the actual classification of ARDS
20 ARDS patients underwent a PET-CT scan at 10 cmH2O. [18F]FDG uptake was determined with the graphical Patlak approach[3] voxel by voxel

Summary

Introduction

In ARDS lung parenchyma presents great variability in inflation, lung inhomogeneities and [18F]FDG uptake. That can activate a local inflammatory response leading to edema

Methods

Conclusions

Gattinoni L