Abstract
Tumour induction has been studied in rodents exposed to radon and its progeny with potential alpha energy concentrations ranging from 600 to 1800 working levels (WL). As part of these studies, the deposition of short-lived radon progeny ( 218Po, 214Pb, and 214Bi) in the lung has been measured in a sample of exposed animals. Exposure conditions were monitored continuously including individual radon progeny concentrations and the ‘unattached’ fractions of 218Po and PAEC. Following exposures under similar conditions of aerosol size (0.15 μm count median diameter) and low ‘unattached’ fraction (<1.5%), it has been possible to establish a relationship between activity deposited in lung and the potential alpha energy concentration. These data have also allowed the estimation of the absorbed alpha dose to the lungs of the exposed animals. This will allow comparison with the biological effects observed during the lifespan study.
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