Abstract
BackgroundConnective tissue disease increases the risk of lung cancer, but whether rheumatoid arthritis (RA) has an effect on the overall survival (OS) rate in this population has not been well studied.MethodsPatients diagnosed with lung cancer between January 2015 and December 2017 were enrolled in this retrospective analysis. Propensity score matching was performed to balance the baseline of the two groups, whereas the differences between patients with and without RA were compared using survival analysis. Further, the effects of interstitial lung disease (ILD) and qi deficiency on survival in cases of RA with lung cancer were examined. Cox regression analysis was applied to predict the factors that influenced the survival of lung cancer to one year.ResultsOverall, 154 lung cancer patients, including 136 (88.3%) without RA and 18 (11.7%) with RA, were included. Two comparison cohorts were matched by 1:2 propensity score matching, which yielded 18 lung cancer patients with RA and 36 lung cancer patients without RA. Ultimately, the survival prognosis of lung cancer and RA was worse than that without RA, that of patients with ILD with RA and lung cancer was worse than that among those without RA, and that of patients with qi deficiency with RA and lung cancer was worse than that among those without RA.ConclusionsThe survival prognosis of lung cancer patients with RA is worse than that of those without RA. ILD and qi deficiency promote reduced survival when found in conjunction with RA in patients with lung cancer.
Highlights
Connective tissue disease (CTD) with lung cancer is a special type of lung cancer
Available data suggest that dermatomyositis (DM), rheumatoid arthritis (RA), and systemic sclerosis (SSc)[2,3,4] increase the risk of lung cancer, but no literature report on whether or not RA has an effect on the survival rate in lung cancer exists at this time
Chronic inflammation leads to excessive tissue remodeling, loss of tissue architecture, and modifications to DNA and proteins as a consequence of oxidative stress, which all increase the risk for cancer development.[7]
Summary
Connective tissue disease (CTD) with lung cancer is a special type of lung cancer. A historical cohort study revealed that CTD increased patients’ risk of lung cancer but had no significant effect on the overall survival.[1]. We conducted a retrospective study to investigate the effects of RA with or without ILD and qi deficiency symptoms on lung cancer survival. Connective tissue disease increases the risk of lung cancer, but whether rheumatoid arthritis (RA) has an effect on the overall survival (OS) rate in this population has not been well studied. Propensity score matching was performed to balance the baseline of the two groups, whereas the differences between patients with and without RA were compared using survival analysis. The effects of interstitial lung disease (ILD) and qi deficiency on survival in cases of RA with lung cancer were examined. ILD and qi deficiency promote reduced survival when found in conjunction with RA in patients with lung cancer
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
