Lung Cancer CT Screening and Lung-RADS in a Tuberculosis-endemic Country: The Korean Lung Cancer Screening Project (K-LUCAS)

Abstract

Background Low-dose CT screening for lung cancer in a tuberculosis-endemic country may be less effective because of false-positive results caused by tuberculosis sequelae. Purpose To evaluate the impact of tuberculosis sequelae at CT screening according to the American College of Radiology Lung CT Screening Reporting and Data System (Lung-RADS) using data from the Korean Lung Cancer Screening Project (K-LUCAS). Materials and Methods This is a secondary analysis of K-LUCAS (ClinicalTrials.gov identifier NCT03394703), a nationwide Asian population-based, multicenter, prospective cohort study. Participants at high risk for lung cancer were enrolled between April 2017 and December 2018. Associations of tuberculosis sequelae with a positive screening result for lung cancer (defined as Lung-RADS categories 3 or 4) and diagnosis of lung cancer were analyzed with multivariable logistic regression. The diagnostic performance of Lung-RADS in predicting lung cancer was compared between participants with and participants without tuberculosis sequelae by using the χ2 test. Results A total of 11 394 participants (median age, 62 years; interquartile range, 58-67 years; 11 098 men) were evaluated. Positive screening results were found in 1868 of the 11 394 participants (16%); lung cancer was diagnosed in 65 of the 11 394 participants (0.6%). Tuberculosis sequelae were identified in 1509 of the 11 394 participants (13%) on the basis of CT scans. Tuberculosis sequelae were associated with positive CT screening results (odds ratio [OR] with one nodule, 1.22; 95% confidence interval [CI]: 1.02, 1.45; P = .03), but no evidence was found of an association with lung cancer (OR, 0.9; 95% CI: 0.4, 1.6; P = .64). Specificity of Lung-RADS was higher for participants without tuberculosis sequelae (85% [8327 of 9829 participants]; 95% CI: 84.0%, 85.4%) than for those with tuberculosis sequelae (80% [1198 of 1500 participants]; 95% CI: 77.7%, 82%; P < .001). Sensitivity was not different between participants with tuberculosis sequelae (100% [nine of nine participants]; 95% CI: 62.9%, 100%) and those without tuberculosis sequelae (98% [55 of 56 participants]; 95% CI: 89.2%, 99.9%; P > .99). Conclusion In an at-risk population, tuberculosis sequelae resulted in a reduced specificity of CT screening for lung cancer using the Lung CT Screening Reporting and Data System. © RSNA, 2020 Online supplemental material is available for this article. See also the editorial by Ketai in this issue.