Abstract
Nicotine present in smoking and tobacco is major cause of occurrence of lung cancer. The basic nature of nicotine helps in easy absorption through lungs. The binding of nicotine and its derivatives to Nicotinic Acetylcholine Receptor results in significant polymorphic mutations in genes coding the subunits of receptors in various populations like Asian and Caucasians which increases the susceptibility of lung cancer in these populations.
Highlights
Lung cancer is the third most common cancer after prostate gland and breast cancer
The nAChRs expressed in lung epithelial cells, are activated by binding of nicotine and NNK leads to opening of ion channels and increase in calcium influx in the cell
Plethora of studies has been done to observe the polymorphic mutations in receptor coding gene in the different population
Summary
Bharti M1* and Yashila G2 1National Institute of Pharmaceutical Education and Research, Mohali, Punjab-160 062, India 2Department of Biotechnology, Thapar University, Patiala, Punjab-147 002, India Bharti and Yashila, J Chromatogr Sep Tech 2016, 7:2 DOI: 10.4172/2157-7064.1000319
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