Abstract
IntroductionLung cancer with large cyst formation is relatively rare. This is a case report of a patient with lung cystic adenocarcinoma with multiple histologic patterns. This type of lung adenocarcinoma is believed to be the first reported case in English language medical literature.Case presentationA 60-year-old Japanese woman was admitted to hospital complaining of dyspnea and died of respiratory failure. She had been suffering from lung cancer with pleural effusion for five years. Autopsy analysis revealed lung adenocarcinoma with large cyst formation showing a variety of histologic patterns.ConclusionsAutopsy analysis of this atypical case of lung cancer may provide insight and lead to a better understanding of the heterogeneity and clonal expansion of lung adenocarcinoma.
Highlights
Lung cancer with large cyst formation is relatively rare
This report is from an autopsy of a patient with lung adenocarcinoma with large cyst formation showing a variety of histologic patterns
Cytological examination was performed on the pleural effusion and the tumor was diagnosed as a conventional adenocarcinoma
Summary
Lung adenocarcinoma with large cyst formation is relatively rare and only a few cases have been reported [1,2,3,4,5,6]. This report is from an autopsy of a patient with lung adenocarcinoma with large cyst formation showing a variety of histologic patterns. Case presentation A 60-year-old Japanese woman was admitted to hospital complaining of dyspnea She had lung cancer with pleural effusion. The pleural effusion had been controlled by drainage and chemotherapy The lesion on her right lung showed an atypical appearance with giant pseudocyst formation, probably containing pleural effusion. Her right lung, weighing 655 g, had a large cyst containing pleural effusion (950 ml) and necrotic tissue (385 g) (Figure 1A, B). A sarcomatous component was found in the mural nodule of the cyst and it was revealed on immunohistochemistry that it was positive for cytokeratin (clone: CAM5.2, image not shown)
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