Luminol immobilized on the metal–organic framework: As an efficient and highly sensitive sensor for the detection of antibiotics in aqueous medium

Abstract

In this research, an anionic metal–organic framework (MOF) with the general formula of [HDMA]2[Zn2(BDC)3(DMA)2]·6DMF (HDMA+: dimethylamonnium, BDC2−: 1,4‐benzenedicarboxilate, DMA: dimethylamine, and DMF: N,N′‐dimethylformamide), namely, TMU‐3, was synthesized by the solvothermal method and then modified with the chemiluminescent reagent of luminol via post‐synthetic modification. The Luminol@TMU‐3 was incorporated as an ideal sensor for the immediate detection of four kinds of antibiotics such as cephalexin, amoxicillin, ampicillin, and 6‐aminopenicillanic acid (6‐APA) in aqueous media. Based on the results, Luminol@TMU‐3 exhibits high throughput and high efficiency of luminescent intensity, and the limit of detection (LOD) of cephalexin (in the 0.001 to 1000 μM concentration range), amoxicillin (in the 0.05 to 100 μM concentration range), ampicillin (in the 0.05 to 100 μM concentration range), and 6‐APA (in the 0.001 to 500 μM concentration range) is estimated to be 0.00005, 0.0001, 0.00012, and 0.00003 μM, respectively. High sensitivity, high throughput, and high fidelity are some of the notable features of this unique diagnostic platform, which can act as a universal device in the quantitative and rapid recognition of a wide range of analytes.