Luminescent Complexes of Co(II), Ni(II), Cu(II), Zn(II)and Bi(III) with 2-Aminothiazole based Ligand and their Biological Studies

Ayesha Kanwal,Mohammed Rafi Shaik,Muhammad Imran,Abdulrahman Al-Warthan,Syed Farooq Adil

doi:10.37358/rc.20.2.7930

Abstract

3-(thiazol-2-yl carbamoyl) propanoic acid was synthesized by the reaction of 2-aminothiazole and succinic anhydride, which was employed as ligand (LH) for further reaction with Co(II), Ni(II), Cu(II), Zn(II) and Bi(III) chlorides at ambient conditions to afford respective metal complexes, denoted as Co-L2, Ni-L2, Cu-L2, Zn-L2 and Bi-L3. Both the ligand LH and metal complexes were characterized by techniques FT-IR, 1H-NMR, 13C-NMR, powder XRD, TGA and conductometry. FT-IR and NMR studies revealed that ligand (LH) behaved in anisobidentate fashion via carboxylate moiety. The ligand and metal complexes are also screened for their antibacterial and antifungal potential and found non-significant activities by most of the complexes, luminescent studies were also made and found Bi-L3 appreciably luminescent.

Highlights

Experimental part MaterialsAminothiazole (Sigma aldrich; m.p: 91-93oC), Acetic Acid (b.p:118.1°C), Succinic anhydride (M & B Chem; m.p 117-119 oC), Methanol (b.p: 78 °C), CoCl2.6H2O (Uni chem; m.p: 86°C), NiCl2.6H2O (United Lab; m.p: 140 °C), CuCl2 (Fluka Chemika; m.p: 498 °C), ZnCl2 (Riedel-de-Haen; m.p: 290 oC), BiCl3 (Beijing chem.; m.p: 227°C), KOH were used without purification
3-(thiazol-2-yl carbamoyl) propanoic acid was synthesized by the reaction of 2-aminothiazole and succinic anhydride, which was employed as ligand (LH) for further reaction with Co(II), Ni(II), Cu(II), Zn(II) and Bi(III) chlorides at ambient conditions to afford respective metal complexes, denoted as Co-L2, Ni-L2, Cu-L2, Zn-L2 and Bi-L3
Keeping in view structural/luminescence/biological importance of 2-aminothiazole, in this study, we report the coupling of 2-aminothiazole with succinic anhydride to yield the carboxylate bearing ligand LH, which was further complexed with various metal ions such as Co(II), Ni(II), Cu(II), Zn(II) and Bi(III) to afford ligand-metal complexes

Summary

Experimental part Materials

Aminothiazole (Sigma aldrich; m.p: 91-93oC), Acetic Acid (b.p:118.1°C), Succinic anhydride (M & B Chem; m.p 117-119 oC), Methanol (b.p: 78 °C), CoCl2.6H2O (Uni chem; m.p: 86°C), NiCl2.6H2O (United Lab; m.p: 140 °C), CuCl2 (Fluka Chemika; m.p: 498 °C), ZnCl2 (Riedel-de-Haen; m.p: 290 oC), BiCl3 (Beijing chem.; m.p: 227°C), KOH were used without purification. The solution was stirred over night at room temperature The resulting solution was concentrated at 40 °C for few hours and straw colored precipitates were obtained. These precipitates were washed with small amount of methanol and n-hexane, recrystallized from hot methanol, dried and stored in desiccator for further use. The resulting mixture was stirred at room temperature for 1 hour and concentrated up to half This concentration resulted precipitates, which were washed with small amount of methanol and n-hexane and dried. For further analysis, these were stored in desiccator

Results and discussions

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Luminescence Studies

Conclusions