Luminal mapping reveals mesenteric predominance of colonic adenomas and adenocarcinomas.

Abstract

Previous studies have examined the relationship between colorectal tumor distribution and metastasis, but the tumor luminal location and associative risk factors promoting tumor growth remain unknown. In this study, we mapped the luminal distribution of human colonic adenomas/adenocarcinomas and their association with various physiologic parameters. We identified a mesenteric predominance for colonic adenomas and adenocarcinomas. The findings of this study raise the possibility of novel mechanistic pathways in the development of adenomas and subsequent transformation into adenocarcinomas.