Abstract
BackgroundTo understand the molecular basis of temporomandibular joint (TMJ) pathologies, we aimed to investigate the lubricin levels in the TMJ synovial fluid (SF) of patients with mild to severe internal derangements (IDs).Material and MethodsA total, 34 joints were the study group. Only patients, with a Wilkes stage of III, IV and V were included, in this sample. Control group consisted of SF from eight joints, from patients undergoing to orthognatic surgery. Concentrations of lubricin in the SF from both samples were measured using ELISA system.ResultsThe mean lubricin concentration was 7.029 ± 0.21 µg/mL in stage III patients; 5.64 ± 0.10 µg/mL in stage IV patients, and 4.78 ± 0.11 µg/mL in stage V patients. The lubricin levels from stage IV and stage V patients differed significantly (P ≤ 0.001) from those of control subjects. Lubricin levels were inversely correlated with age and to VAS score.ConclusionsThe results of this cross-sectional study highlight the relationship between disease severity and the levels of lubricin in TMJ SF. Our findings suggest that novel biotherapeutic approaches, including the administration of recombinant lubricin in the joint cavity, for the treatment of TMJ diseases can be developed. Key words:Lubricin, TMJ, derangements, synovial fluid.
Highlights
Temporomandibular disorders (TMDs) are conditions that affect the temporomandibular joint (TMJ) and related musculoskeletal structures
Background: To understand the molecular basis of temporomandibular joint (TMJ) pathologies, we aimed to investigate the lubricin levels in the TMJ synovial fluid (SF) of patients with mild to severe internal derangements (IDs)
Following a traumatic knee injury, articular cartilage surfaces are predisposed to wear-induced damage because of the resultant changes in joint lubricating mechanisms, which are mediated by lubricin catabolism, and down-regulation due to elevated inflammatory cytokines levels [17]
Summary
Temporomandibular disorders (TMDs) are conditions that affect the temporomandibular joint (TMJ) and related musculoskeletal structures. These disorders are divided into classical myofascial pain, internal derangement (ID), and osteoarthrosis (OA) [1]. In order to gain a better understanding of the degenerative change mechanism and the molecular basis of OA etiopathogenesis, we decided to use this study to investigate the lubricin levels in the TMJ SF of patients with mild to severe ID. To understand the molecular basis of temporomandibular joint (TMJ) pathologies, we aimed to investigate the lubricin levels in the TMJ synovial fluid (SF) of patients with mild to severe internal derangements (IDs). Conclusions: The results of this cross-sectional study highlight the relationship between disease severity and the levels of lubricin in TMJ SF. Our findings suggest that novel biotherapeutic approaches, including the administration of recombinant lubricin in the joint cavity, for the treatment of TMJ diseases can be developed
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