Abstract
We are investigating the use of Scanning Doppler Velocimetry to evaluate changes in tissue perfusion that occur during Photodynamic Therapy (PDT). In initial studies, this technique was used to assess changes in tissue perfusion in mice given PDT using Photofrin, Purlytin, or Lutrin. There was a rapid and complete loss of perfusion in both normal tissue and tumor in animals given PDT using Photofrin. Using Purlytin, there was immediate loss of perfusion at the tumor site. For PDT using Lutrin, there was a lot of perfusion in the tumor with relatively no change in the surrounding normal skin, confirming the high degree of selectivity of PDT with this photosensitizer. These reductions in persistent through at least 24 h after PDT.
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