Abstract
ABSTRACT In the last few years there have been a number of research papers on self-assemblies of molecules as 'advancedmaterials 'or'smart sensors '. The inspiration for this exciting research, without question, comes from the biological world,where, for example, the lipid bilayer of the cell membrane is the most important seff-a.ssembling system. Although the firstreport on self-assembled bilayer lipid membranes (BLMs) in vitro was published in 1962, interface science includingsurface and colloid science has been dealing with these interfacial self-assemblies of amphiphiic molecules since RobertHooke's time (1672). In this communication, we present results of extensive study of physical chemical properties of twonew membrane systems: metal and hydrogel supported bilayer lipid membranes (BLMs for short, also known as planar lipidbilayers). Several methods have been used to investigate the properties of these metal supported s-BLMs and hydrogelsupported salt-bridge sb-BLMs. With the elecirostriction method we observed different behavior of the planar lipid bilayeron metal substrate. The obtained results gave possibility to choose optimal properties of the support for constructing s-BLM-based biosensors. The capacitance relaxation method was used to determine the changes of dieleciric relaxation times(reorientation of dipole moments of polar groups of individual lipid molecules or lipid clusters) and showed differentdynamic properties oflipids on the metal substrate and in free standing BLMs. Analysis of membrane current noise allowedthe examination of the dynamic properties of supported BLMs. Examples of a number of practical applications of s-BLMsfor the construction of a glucose sensor for biomedical use as well as applications of agar supported BLMs for determiningseveral toxins will be presented.(Keywords: bilayer lipid membranes, BLMs, planar lipid bilayers, biosensors, metal substrate, hydrogels, agar, inteiface)1. INTRODUCTION
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