Abstract
In the process of developing optical tomographic imaging systems for diagnosis of disease and study of brain functions of human heads, we need realistic optical phantoms which anatomically and optically simulate human heads with complicated and multi-layered structures. Previously we have reported design and fabrication methods of optical head phantoms based on MRI images of a human head. The phantoms were simulated the multilayered structure with different optical properties at five layers; i.e., skin, skull, cerebrospinal fluid layer, gray matter and white matter. Also the phantoms which were mainly made of solid resin had dynamic parts to simulate the temporal variation of physiological functions in brain. The optical properties of the liquid circulating through the dynamic part can be changed to simulate the change in oxygenation states. The material of the skin layer has been changed from solid resin to soft rubber in order to have a good contact with optical fibers. The fabricated optical head phantom has been used in time-resolved spectroscopic measurement, and the usefulness of the dynamic optical head phantom is verified.
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